Information from its description page there is shown below. Officially, while an industrial chemical dnp is pure poison. After 43 days of taking dnp, the man showed signs of intoxication with nausea, vomiting, and attacks of sweating. To prepare the energy inhibitor 2, 4 dinitrophenol stock solution, 2, 4 dinitrophenol was precisely weighed at 0. Dnp is used in developing photography, killing fungi, and as an industrial pesticide. Electronic spectrum of 2,4dinitrophenol in a 2 m solution of ammonia.
Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. The atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. A phenolate anion obtained from 2, 4 dinitrophenol. Show this safety data sheet to the doctor in attendance. Stars this entity has been manually annotated by the chebi team. This material does not contain any class 2 ozone depletors. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and i was on an ankle monitor and stuck at home at the time, which made it pretty hard for me to get any exercise. Other pertinent literature is also presented, but is described in less detail than the key studies.
Update of human health ambient water quality criteria. These features are all too frequently fatal in spite of intensive medical treatment. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Buy dnp 2,4dinitrophenol not for human consumption. Aldifen alphadinitrophenol 1hydroxy2,4dinitrobenzene keep people away. The laccase immobilization was done based on gianfreda and bollag 1994 and ruggiero et al. Dinitrophenol for weight loss has been used for almost a hundred years, but was officially deprived of medical drug status in 1938 due to the high toxicity and a variety of side effects.
The dissociation or uncoupling of phosphorylation from electron transport by 2,4dinitrophenol was first described by loomis and lipmann in 1948 1. It was synthesised in a multistep reaction, starting. Our evidencebased analysis on 2, 4 dinitrophenol features 23 unique references to scientific papers. Like picric acid 2,4 6trinitrophenol, 2, 4dinitrophenol is a powerful explosive material. The mechanism of uncoupling of oxidative phosphorylation by 2. This page is regularly updated, to include the most recently available clinical trial evidence. Dnp is an inhibitor of efficient energy atp production in cells with mitochondria. The halflife of a pollutant is the amount of time it takes for onehalf of the chemical to be degraded.
A year or more ago, i was on an antidepressant regimen that made me gain a lot of weight. Sep 17, 2015 buy dnp 2, 4 dinitrophenol not for human consumption. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture.
Efficient removal of 2,4dinitrophenol from synthetic. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. The acute shortterm effects of 2,4dinitrophenol in humans through oral exposure are nausea, vomiting, sweating, dizziness, headaches, and loss of weight. It is a yellow, crystalline solid that has a sweet, musty odor. There are 20 suppliers who sells dinitrophenol 2 4 on, mainly located in asia. Youve probably seen 2,4dinitrophenylhydrazine referred to alternately as 2,4dnph or 2,4dnp. When in a dry form, it is a high explosive and has an instantaneous explosion hazard. Pdf two deaths attributed to the use of 2,4dinitrophenol. Associations of 2,4dinitrophenol with other chemical compounds gene context of 2,4dinitrophenol analytical, diagnostic and therapeutic context of 2,4dinitrophenol.
Full text full text is available as a scanned copy of the original print version. This material does not contain any class 1 ozone depletors. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. Jan 10, 2004 death within 44 days of 2, 4 dinitrophenol intake we report the case of a 50yearold obese man 115 kg body mass at 1. Commons is a freely licensed media file repository. A few years later demographical statistics showed that employees who worked with. Dinitrophenols are a class of manufactured chemicals that do not occur naturally in the environment. A wide variety of dinitrophenol 2 4 options are available to you, such as medicine grade, industrial grade, and food grade.
It is most often used as an antiseptic and a precursor to sulfur dyes. Incompatible with heavy metals and their compounds. The chemical structure of 2,4dinitrophenol is shown in figure 1. Death within 44 days of 2,4dinitrophenol intake we report the case of a 50yearold obese man 115 kg body mass at 1. Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method.
Dnp types dinitrophenol in the medical field has two possible forms. Get a printable copy pdf file of the complete article 2. First aid measures general advice consult a physician. It has a role as an oxidative phosphorylation inhibitor, a bacterial xenobiotic metabolite and an antiseptic drug. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. The mechanism of uncoupling of oxidative phosphorylation.
Anyway, i learned about a chemical called 2, 4 dinitrophenol or dnp, which is what they call it in bodybuilding circles. This file is licensed under the creative commons attributionshare alike 4. Dnp by moving protons across the mitochondrial membrane breaks the process of oxidative phosphorylation, whereby there is an active waste of energy, but without the synthesis of adenosine triphosphate molecules. The most commercially important dinitrophenol, 2,4 dinitrophenol dnp, is a yellow solid with no smell. Our evidencebased analysis on 2,4dinitrophenol features 23 unique references to scientific papers. Dinitrophenol for weight loss has been used for almost a hundred years, but was officially deprived of medical drug status in 1938 due to the high. The top countries of suppliers are india, china, from which the percentage of dinitrophenol 2 4 supply is 15%, 80% respectively.
Wear goggles, selfcontained breathing apparatus, and rubber overclothing. William stillwell, in an introduction to biological membranes second edition, 2016. This is a chemical that was once used in the early 20th century to ignite dynamite and cast a yellow dye on wood and other handcrafts. Everything about dnp 2,4dinitrophenol pharma forums. It is used in making dyes, wood preservatives, explosives, insect control substances, and other chemicals, and as a photographic developer. Links to pubmed are also available for selected references. The acute shortterm effects of 2, 4 dinitrophenol in humans through oral exposure are nausea, vomiting, sweating, dizziness, headaches, and loss of weight. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5. Definition a dinitrophenol having the nitro groups at the 2 and 4positions. Dnp is a compound used in the early 1900s as a weight. It is a synthetic lipidsoluble proton ionophore that dissipates proton gradients across bioenergetic membranes mitochondrial inner, thylakoid, bacterial plasma. The compound can often be found in pressure treated wood as a fungicide, in various dyes, used in photograph development and as an insecticide. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this. Aleksander sobolewski via wikimedia commons you are free.
It is also used in the synthesis of coumarins and in the preparation of chloroformates as pharmaceutical reagents. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. Sep 26, 2019 the atsdr toxicological profile succinctly characterizes the toxicologic and adverse health effects information for the hazardous substance described here. Also incompatible with strong oxidizing agents, strong bases and reducing agents. I stopped using that crap, but i was still a bit heavier than i wouldve liked, and it was winter and. Dnp, officially labeled as 2, 4 dinitrophenol, is classified as an industrial chemical.
It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. It uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, leading to a rapid consumption of energy without generation of atp. Strictly speaking, the former is more correct, though the latter is commonly used to refer to it too. Dnp, officially labeled as 2,4dinitrophenol, is classified as an industrial chemical. Aldifen alpha dinitrophenol 1hydroxy 2, 4 dinitrobenzene keep people away. Also incompatible with strong oxidizing agents, strong bases and. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. A few years later demographical statistics showed that employees who worked with dnp everyday tended to lose weight, often rapidly. The activated minerals were then treated with a 5% solution of glutaraldehyde in a 0.
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